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Severe birth defects such as congenital cardiac heart defects malformations and oral clefts cleft lip and or cleft palate have been associated with the use of zofran in the first trimester of pregnancy.

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ZOFRAN is indicated for the prevention of nausea and vomiting associated with:

While doxylamine/pyridoxine is the only FDA-approved medication for morning sicknessdoctors continue to write off-label prescriptions for other medicationsFirst-line alternatives include antihistamines diphenhydramine and meclizinewhich were deemed Pregnancy Risk Category Blike Zofran.

ZOFRAN is not a drug that stimulates gastric or intestinal peristalsisIt should not be used instead of nasogastric suction.

ZOFRAN does not alter the respiratory depressant effects produced by alfentanil or the degree of neuromuscular blockade produced by atracuriumInteractions with general or local anesthetics have not been studied.

Pediatric cases consistent with serotonin syndrome have been reported after inadvertent oral overdoses of ondansetronexceeding estimated ingestion of 5 mg per kgin young childrenReported symptoms included somnolenceagitationtachycardiatachypneahypertensionflushingmydriasisdiaphoresismyoclonic movementshorizontal nystagmushyperreflexiaand seizurePatients required supportive careincluding intubation in some caseswith complete recovery without sequelae within 1 to 2 days.

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i already have nausea and take zofran for the nausea.

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